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dnaX [2019-08-15 09:50:45]
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dnaX [2019-08-15 09:50:45]

DNA polymerase III (gamma and tau subunits) part of the clamp-loader complex and the [SW|replisome]
locus
BSU_00190
pI
5.49
mw
62.53 kDa
protein length
563 aa Sequence Blast
gene length
1692 bp Sequence Blast
function
[category|SW 3.1.1|DNA replication]
product
DNA polymerase III (gamma and tau subunits)
essential
yes
ec
2.7.7.7
synonyms
dnaH,dna-8132
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.1|DNA replication]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

    • Gene

    Coordinates
    26,814 28,505

    Phenotypes of a mutant

  • essential [Pubmed|12682299]

    • The protein

    Catalyzed reaction/ biological activity

  • deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) (according to UniProt)
  • required for bacteriophage SPP1 replication [Pubmed|23268446]

    • Protein family

  • DnaX/STICHEL family (single member, according to UniProt)

    • Structure

  • [PDB|1JR3] (from ''E. coli'', 39% identity) [Pubmed|11525729]

    • [SW|Localization]

  • forms foci [Pubmed|21958350]
  • Nucleoid (Mid-cell) [Pubmed|16479537]

    • Expression and Regulation

    Operons

    genes
    [gene|73D063EDC412F7F28DA27C986ECCCD1C4A1F6618|dnaX]-[gene|9AFCEFE83560B1E2B1FFD7CFD2E4F17FAE137889|yaaK]-[gene|BEBAF1EB53EBB3E7558BB5FE73C418B50000FA29|recR]-[gene|C5127208E7562F09249112240F0BE8C582B2E5AD|yaaL]-[gene|CB5D3A2E5BEE336539BEB2D7C5D9C3A63C78FD01|bofA]
    description
    [Pubmed|22383849]
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    References

  • 16479537,19415803,14757052,12974630,1703271,12466528,20122408,23525462,23268446,21958350,11525729,30686488